Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.

摘要: Objective To compare the effects of single-sitting vs 4-sitting panretinal photocoagulation (PRP) on macular edema in subjects with severe nonproliferative or early proliferative diabetic retinopathy relatively good visual acuity and no mild center-involved edema. Methods Subjects were treated 1 sitting 4 sittings PRP a nonrandomized, prospective, multicentered clinical trial. Main Outcome Measure Central subfield thickness optical coherence tomography (OCT). Results was slightly greater 1-sitting group (n = 84) than 71) at 3-day (P .01) 4-week visits .003). At 34-week primary outcome visit, slight differences had reversed, being .06). Visual paralleled OCT differences. Conclusions Our results suggest that clinically meaningful are unlikely following application compared this cohort. More definitive would require large randomized Application to Clinical Practice These costs some patients terms travel lost productivity as well eye care providers could be reduced. Trial registration clinicaltrials.gov Identifier: NCT00687154.