Incubation of Cue-Induced Craving in Adults Addicted to Cocaine Measured by Electroencephalography

摘要: Importance A common trigger for relapse in drug addiction is the experience of craving via exposure to cues previously associated with use. Preclinical studies have consistently demonstrated incubation cue-induced drug-seeking during initial phase abstinence, followed by a decline over time. In humans, effect has been shown alcohol, nicotine, and methamphetamine addictions, but not heroin or cocaine addiction. Understanding trajectory abstinence humans importance medicine. Objective To assess using both subjective objective indices cue-elicited responses. Design, Setting, Participants Seventy-six individuals addicted varying durations (ie, 2 days, 1 week, month, 6 months, year) participated this laboratory-based cross-sectional study from June 19, 2007, November 26, 2012. The late positive potential component electroencephalography, recognized marker incentive salience, was used track motivated attention across these self-selected groups. also completed ratings before presentation cue, “liking” (hedonic feelings toward cocaine) “wanting” (craving after cocaine-related pictures. Data analysis conducted 5, 2015, March 30, 2016. Main Outcomes Measures amplitudes liking wanting response pictures were quantified compared Results Among 76 cocaine, 19 (25%) abstinent 20 (26%) 15 (20%) 12 (16%) 10 (13%) year. cues, mean (SD) showed parabolic that higher at (1.26 [1.36] µV) (1.17 [1.19] months lower days (0.17 [1.09] µV), week (0.36 [1.26] year (–0.27 [1.74] ( P  = .02, partial η  = 0.16). contrast, assessment baseline (mean [SD] rating: 26.05 [9.85]; 18.70 [11.01]; 10.87 [10.70]; 6.92 [8.47]; year, 3.00 [3.77]) 3.06 [2.34]; 2.33 [2.87]; 1.15 [2.03]; 1.00 [2.24]; [1.26]) 3.44 [2.62]; 2.72 1.46 [2.33]; [2.16]; [1.55]) linear  ≤ .001,  > 0.26). Conclusions Relevance responses indicative attention, similar reported animal models. we did detect craving. Thus, electroencephalographic measure may possibly be better indicator vulnerability than reports craving, although hypothesis must empirically tested. These results suggest deploying intervention between month when most vulnerable to, perhaps least cognizant of, risk relapse.