Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

摘要: Abstract Previous studies have shown that the metabotropic glutamate receptor (mGluR)2/3 agonist LY354740 attenuated release in medial prefrontal cortex (mPFC) induced by non-competitive N -methyl- d -aspartate (NMDA) antagonist phencyclidine. In present study we examined effects of more potent mGluR2/3 selective LY379268 on ketamine-evoked and dopamine (DA) mPFC male rats. Subjects were implanted with a unilateral microdialysis probe tested 12–24 h after implantation. Ketamine (18 mg/kg, s.c.) evoked significant DA, although response was slower onset compared DA. Pretreatment either systemic (3 mg/kg or local (1 μM, probe) blocked glutamate, but not release. When applied directly to via dialysis probe, ketamine mM had no effect did significantly enhance Application NMDA (500 μM probe), other hand, decreased DA while increasing The evoking administration LY379268. These findings indicate increases both can be stimulating group II mGluR receptors. Local ketamine, does increase This suggests acts outside within origin is currently known.