Vaccination against diseases resulting from pathogenic responses by specific T cell populations
作者： Mark D. Howell , Dennis J. Carlo , Steven W. Brostoff
DOI:
关键词: Peptide sequence 、 Biology 、 Virology 、 Immunology 、 Immune system 、 T cell 、 T-cell receptor 、 Vaccination 、 IL-2 receptor 、 Disease 、 Cytotoxic T cell
摘要: The present invention provides vaccines and a means vaccinating host so as to prevent or control specific T cell medicated proliferative diseases. vaccine is composed of pharmaceutically acceptable medium segment the receptor (TCR) on surface cells mediating disease. administered in manner that induces an immune response directed against TCR pathologic cell. This down regulates deletes pathogenic cells, thus ablating disease pathogenesis. Means determining appropriate amino acid sequence for such are also provided.
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