Protective effects of salecan against carbon tetrachloride-induced acute liver injury in mice.
作者： Jianfa Zhang , Peng Chen , Zhongqiu Wang , Liyan Zeng , Shiming Wang
DOI: 10.1002/JAT.1694
关键词: Necrosis 、 Pharmacology 、 Hepatocyte 、 Carbon tetrachloride 、 Immunology 、 Antioxidant 、 CCL4 、 Lipid peroxidation 、 Glutathione 、 Oxidative stress 、 Biology
摘要: Carbon tetrachloride (CCl4) is a well-established model for screening hepato-protective drugs. The aim of the present study was to evaluate potential protective effects novel soluble β-glucan salecan on acute liver injury induced by CCl4 in mice and further explore underlying mechanisms. Mice were given (40 mg kg−1) or phosphate-buffered saline 3 days prior treatment with single intraperitoneal dose (1 ml kg−1 body weight). Animals sacrificed at 0, 12, 24, 48, 72 96 h post-injection CCl4. Serum enzyme levels, histology, lipid peroxidation, glutathione (GSH) content, expression antioxidant enzymes hepatocyte proliferation subsequently evaluated. serum levels hepatic markers markedly reduced pretreatment group compared control group. Histopathological examination livers revealed that hepatocellular degeneration necrosis significantly attenuated an early stage during intoxication recovery accelerated later pre-administered mice. Furthermore, administration remarkably alleviated peroxidation restored GSH depletion. Meanwhile, genes elevated salecan-treated Interestingly, enhanced phase after injection. Taken together, these results demonstrated exhibits action through attenuating oxidative stress accelerating regeneration. Copyright © 2011 John Wiley & Sons, Ltd.
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