Asymmetric DNA methylation between sister chromatids of metaphase chromosomes in mouse embryos upon bisphenol A action.
作者： E.L. Patkin , N.A. Grudinina , L.K. Sasina , E.M. Noniashvili , L.I. Pavlinova
DOI: 10.1016/J.REPROTOX.2017.08.017
关键词: Asymmetric cell division 、 Stem cell 、 DNA methylation 、 Sister chromatids 、 Molecular biology 、 Embryo 、 Biology 、 Metaphase 、 Cell culture 、 Methylation
摘要: Abstract Earlier we showed that asymmetric methylation of sister chromatids (AMSC) was a specific characteristic differentiation potency, and supposed AMSC could be useful marker environmental impact connected with and/or dedifferentiation. Here investigated the level in chromosomes nuclei mouse preimplantation postimplantation embryos, comparison undifferentiated cells embryonal carcinoma cell line F9, human differentiated HEK293 upon BPA influence. We found exposure embryos to caused significant decrease methylation. The potentially differentiating F9 had no any influence on DNA but significantly decreased number AMSC. were not also changed. These data indicate exerts differentiable cells. most sensitive targets are stem
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