The evaluation of data-derived safety factors for bis(tri-n-butyltin)oxide.
作者： Andre H. Penninks
DOI: 10.1080/02652039309374157
关键词: Bis(tri-n-butyltin)oxide 、 Tolerable daily intake 、 Chemistry 、 Toxicity 、 Toxicology 、 Pharmacology
摘要: In this report the evaluation of a safety factor is assessed, according to decision tree suggested by Renwick (1991a,b), determine Tolerable Daily Intake (TDI) value for environmental contaminant bis(tri‐n‐butyltin)oxide (TBTO). Based on available literature nature most sensitive parameter TBTO‐toxicity was perceived be lymphoid organs and function. Subsequently, factors were derived in relation published data inter‐species inter‐individual differences both kinetics dynamics TBTO. Lack information human concerning toxicity as well TBTO finally resulted 100. A TDI 5 or 0.25 mg/kg bw per day assessed based reductions organ weights (thymus) function (resistance T. spiralis), respectively. addition, rodents TBTO, it that combined tri‐ di...
sci-hub.se 参考文章(48)
M. Bol, W. Seinen, R. H. H. Pieters, B. W. Lam, A. H. Penninks, The organotin-induced thymus atrophy, characterized by depletion of CD4+ CD8+ thymocytes, is preceded by a reduction of the immature CD4- CD8+ TcR alpha beta-/low CD2high thymoblast subset. Immunology. ,vol. 76, pp. 203- 208 ,(1992)
A. H. Penninks, W. Seinen, Immunotoxicity of Organotin Compounds. A Cell Biological Approach to Dialkyltin Induced Thymus Atrophy Springer, Dordrecht. pp. 258- 278 ,(1987) , 10.1007/978-94-009-4307-0_19
Zdeněk Pelikán, Emil Černý, Die toxische Wirkung von Tri-n-butylzinn-Verbindungen auf weiße Mäuse Fühner-Wielands Sammlung von Vergiftungsfällen Archiv für Toxikologie. ,vol. 23, pp. 283- 292 ,(1968) , 10.1007/BF00577535
A.H. PENNINKS, W. SEINEN, The Lymphocyte as Target of Toxicity: a Biochemical Approach to Dialkyltin Induced Immunosuppression Advances in Immunopharmacology#R##N#Proceedings of the Second International Conference on Immunopharmacology, July 1982, Washington, USA. pp. 41- 60 ,(1983) , 10.1016/B978-0-08-029775-0.50009-2
Shunichi Fujita, T. H. Yu, Mariko Hihara, Yasuaki Arakawa, Nobuyuki Yamazaki, Immunotoxicity of organotin compounds Journal of Toxicological Sciences. ,vol. 6, pp. 237- ,(1981)
Nate F. Cardarelli, Controlled release pesticide formulations CRC Press. ,(1976)
J.G. Vos, A. de Klerk, E.I. Krajnc, W. Kruizinga, B. van Ommen, J. Rozing, Toxicity of bis(tri-n-butyltin)oxide in the rat: II. Suppression of thymus-dependent immune responses and of parameters of nonspecific resistance after short-term exposure Toxicology and Applied Pharmacology. ,vol. 75, pp. 387- 408 ,(1984) , 10.1016/0041-008X(84)90177-7
E.I. Krajnc, P.W. Wester, J.G. Loeber, F.X.R. van Leeuwen, J.G. Vos, H.A.M.G. Vaessen, C.A. van der Heijden, Toxicity of bis(tri-n-butyltin)oxide in the rat: I. Short-term effects on general parameters and on the endocrine and lymphoid systems Toxicology and Applied Pharmacology. ,vol. 75, pp. 363- 386 ,(1984) , 10.1016/0041-008X(84)90176-5
W T Piver, Organotin compounds: industrial applications and biological investigation. Environmental Health Perspectives. ,vol. 4, pp. 61- 79 ,(1973) , 10.1289/EHP.730461
A. G. Renwick, Data‐derived safety factors for the evaluation of food additives and environmental contaminants Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment. ,vol. 10, pp. 275- 305 ,(1993) , 10.1080/02652039309374152