The Interaction Between the Metabolism of Retinol and Ethanol in Esophageal Mucosa – A Possible Mechanism of Esophageal Cancer in Alcoholics

作者: Hirokazu Yokoyama , Haruko-Shiraishi Yokoyama , Toshifumi Hibi

DOI: 10.5772/37383

关键词: MetabolismVitaminInternal medicineChemistryGastroenterologyIn vivoRetinolRetinoidPathogenesisEsophageal cancerCancer researchMechanism (biology)

摘要: Recently, aberrant statuses of retinoids, which are structurally and/or functionally related to vitamin A (retinol), have been implicated in the pathogenesis some types cancers. It is well established that, at least natural conditions, retinoic acids (RAs) mainly responsible for retinoid actions among various retinoids. current consensus that RAs supplied via retinol metabolisms vivo.

参考文章(90)
B. Shroot, J. A. Fontana, M. I. Dawson, J. V. Ordonez, Q. X. Han, A. K. Rishi, M. S. Sheikh, X. S. Li, Zhimin Shao, p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells Oncogene. ,vol. 11, pp. 493- 504 ,(1995)
William F. Bosron, Ting-Kai Li, Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme. ,vol. 37, pp. 19- 28 ,(1987) , 10.1159/000469238
ANITA B. ROBERTS, MICHAEL B. SPORN, Cellular Biology and Biochemistry of the Retinoids The Retinoids. pp. 209- 286 ,(1984) , 10.1016/B978-0-12-658102-7.50012-9
Charles S. Lieber, Maria A. Leo, Alcohol and the Liver Springer, Boston, MA. pp. 185- 239 ,(1992) , 10.1007/978-1-4615-3320-7_7
Walter N. Hittelman, Jhingook Kim, Jae Y. Ro, Jack A. Roth, Waun K. Hong, Dong M. Shin, Jason Hittelman, Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis Cancer Research. ,vol. 54, pp. 321- 326 ,(1994)
Brett Wallden, Mary Emond, Mari E Swift, Mary L Disis, Karen Swisshelm, Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells BMC Cancer. ,vol. 5, pp. 140- 140 ,(2005) , 10.1186/1471-2407-5-140
Andreas Widschwendter, Martin Widschwendter, Elisabeth Müller-Holzner, Alain G. Zeimet, Günter Daxenbichler, Jennifer Berger, Adelcy Mayr, Christian Marth, Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer Cancer Research. ,vol. 57, pp. 4158- 4161 ,(1997)
Reuben Lotan, Chang-Ping Zou, John L. Clifford, Waun K. Hong, Xiao-Chun Xu, Peter G. Sacks, Pierre Chambon, Modulation by Retinoic Acid (RA) of Squamous Cell Differentiation, Cellular RA-binding Proteins, and Nuclear RA Receptors in Human Head and Neck Squamous Cell Carcinoma Cell Lines Cancer Research. ,vol. 54, pp. 5479- 5487 ,(1994)
Chung S. Yang, Hongkun Gao, Tong-Yuh Huang, Li-Dong Wang, Jun-Yan Hong, Qi Zhou, p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China. Cancer Research. ,vol. 54, pp. 4342- 4346 ,(1994)