Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease.
作者： D.Allan Butterfield , Servet M. Yatin , Sridhar Varadarajan , Tanuja Koppal
DOI: 10.1016/S0076-6879(99)09050-3
关键词: Alzheimer's disease 、 Amyloid beta 、 Lipid peroxidation 、 Cancer research 、 Oxidative stress 、 Biochemistry 、 Protein oxidation 、 Neurotoxicity 、 Mitochondrion 、 Free-radical theory of aging 、 Chemistry
摘要: Given the increasing evidence of oxidative stress in AD brain and studies from different perspectives that appear to show a converging, central role for A beta pathogenesis etiology AD, insight into beta-associated free radical will likely lead greater understanding and, potentially, better therapeutic strategies this disorder. This article outlined methods investigate markers induced by membrane systems. Especially important are protein oxidation, lipid peroxidation, ROS generation beta. Oxidative its sequelae related both necrotic apoptotic mechanisms neurotoxicity, may be fundamental importance Alzheimer's disease pathogenesis. The described here provide some means investigating possibility.
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