Studies on the migration inhibitory factor associated with delayed-type hypersensitivity: cytodynamics and specificity.

摘要: SUMMARY Peritoneal lymphocytes obtained from tuberculin sensitive guinea pigs, when cultured with purified protein derivative, elaborate into the medium a substance, presumably protein, capable of inhibiting migration normal macrophages. This inhibitory factor appears to possess immunologic specificity, since specific antigen enhances its activity. Sensitized cells upon interaction continuously produce this for up 4 days. Concomitantly, sensitized undergo those morphologic alterations recognized as “blast-cell” transformation.