Quantitative analysis of therapeutic drugs in dried blood spot samples by paper spray mass spectrometry: an avenue to therapeutic drug monitoring.
作者： Nicholas Edward Manicke , Paul Abu-Rabie , Neil Spooner , Zheng Ouyang , R Graham Cooks
DOI: 10.1007/S13361-011-0177-X
关键词: Whole blood 、 Dried blood spot 、 Chemistry 、 Mass spectrometry 、 Detection limit 、 Therapeutic drug monitoring 、 Sample preparation 、 Standard solution 、 Quantitative analysis (chemistry) 、 Chromatography
摘要: A method is presented for the direct quantitative analysis of therapeutic drugs from dried blood spot samples by mass spectrometry. The method, paper spray spectrometry, generates gas phase ions directly card used to store without need complex sample preparation and separation; entire time around 30 s. Limits detection were investigated a chemically diverse set some 15 drugs; hydrophobic weakly basic drugs, such as sunitinib, citalopram, verapamil, found be routinely detectable at approximately 1 ng/mL. Samples prepared addition drug whole blood. Drug concentrations measured quantitatively over several orders magnitude, with accuracies within 10% expected value relative standard deviation (RSD) prespotting an internal solution onto prior application sample. We have demonstrated that spectrometry can measure range wide variety drugs. high quality analytical data obtained indicate technique may viable option monitoring.
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