Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates?
作者： J.D. Schrag , F.K. Winkler , M Cygler
DOI: 10.1016/S0021-9258(18)42832-3
关键词: Catalytic triad 、 Enzyme 、 Peptide sequence 、 Sequence alignment 、 Biochemistry 、 Protein structure 、 Serine 、 Lipoprotein lipase 、 Amino acid 、 Biology
摘要: Comparison of the fold lipases from Geotrichum candidum and human pancreas identified a high degree similarity which was not expected on basis their amino acid sequences. Although both enzymes utilize serine protease-like catalytic triad, they differ in topological position acid. We speculate that these proteins are evolutionarily related pancreatic lipase is an evolutionary intermediate pathway migration to new within fold.
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