High expression of MAP7 predicts adverse prognosis in young patients with cytogenetically normal acute myeloid leukemia
作者： Lin Fu , Huaping Fu , Lei Zhou , Keman Xu , Yifan Pang
DOI: 10.1038/SREP34546
关键词: Cell signaling pathways 、 Prognostic biomarker 、 Microarray 、 microRNA 、 Leukemia 、 Medicine 、 Cancer research 、 Cancer cell 、 Gene 、 Cytogenetically normal acute myeloid leukemia
摘要: Microtubule-associated protein 7 (MAP7) plays an important role in cancer cells. In this study, we identified the prognostic significance of MAP7 expression cytogenetically normal acute myeloid leukemia (CN-AML) patients (aged <60 years) based on several microarray datasets. first group (n = 129), high (MAP7high) was associated with adverse overall survival (OS; P = 0.0441) and event-free (EFS; P = 0.0114) compared low (MAP7low). addition, confirmed by European Leukemia Net (ELN) intermediate-I genetic categories multivariable analysis. second independent CN-AML years), MAP7high also OS (n = 88, OS; P = 0.00811). To understand inherent mechanisms MAP7’s prognosis, investigated genome-wide gene/microRNA signatures expression. Several known oncogenic genes/microRNAs anti-oncogenic were disordered patients. conclusion, is biomarker for CN-AML, which may be attributed to distinctive related cell signaling pathways.
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