Limits of Tolerance to Hypothermia

摘要: Abstract : With the advent of sophisticated rewarming techniques, physiologic systems demonstrate great tolerance to hypothermia. Organs can be cooled, and in some cases frozen, leading a decrease metabolic demands then rewarmed with little or no long-term damage. Not all hypothermia are reversed rewarming. The major challenge for extending limits is ascertain fundamental mechanisms that unleashed upon microvasculature remains key site human currently favored hypothesis frostbit- induced damage free radicals released by reperfusion subsequently alter vascular tone. Eventually, these changes cause failure microcirculation endothelial cell damage, resulting thrombosis necrosis. It probable same cascade events occurs frostbite also during hypothermic patient. Predicting which system will fail difficult since many secondary underlying pathology. This review focus on two aspects cold: 1) effects occur hypothermia, 2) role various forms play reversing