Screening of plants used in Danish folk medicine to treat epilepsy and convulsions.

作者: Anna K. Jäger , Bente Gauguin , Anne Adsersen , Lene Gudiksen

DOI: 10.1016/J.JEP.2005.10.015

关键词: ConvulsionTanacetum partheniumPrimulaPharmacologyScreening testEpilepsyPharmacognosyPrimula elatiorFolk medicineMedicine

摘要: Abstract Aqueous and ethanolic extracts of 42 plants used in Danish folk medicine for the treatment epilepsy convulsions, or inducing sedation, were tested affinity to GABAA–benzodiazepine receptor flumazenil-binding assay. Ethanolic leaves Primula elatior veris aerial parts Tanacetum parthenium exhibited good, dose-dependent affinity.

参考文章(13)
Maurice M. Iwu, Jacqueline C. Wootton, Ethnomedicine and drug discovery Ethnomedicine and drug discovery.. ,(2002)
Elaine Elisabetsky, Traditional medicines and the new paradigm of psychotropic drug action Advances in Phytomedicine. ,vol. 1, pp. 133- 144 ,(2002) , 10.1016/S1572-557X(02)80020-4
J.H. Medina, C. Peña, M. Levi de Stein, C. Wolfman, A.C. Paladini, Benzodiazepine-like molecules, as well as other ligands for the brain benzodiazepine receptors, are relatively common constituents of plants Biochemical and Biophysical Research Communications. ,vol. 165, pp. 547- 553 ,(1989) , 10.1016/S0006-291X(89)80001-4
Kenneth Hayataka, Nancy Colson, Rustem Medora, Ethan B. Russo, Keith K. Parker, John T. Weber, Mary-Frances O'Connor, Activity of Parthenolide at 5HT2A Receptors Journal of Natural Products. ,vol. 60, pp. 651- 653 ,(1997) , 10.1021/NP960644D
Gary I. Stafford, Anna K. Jäger, Johannes van Staden, Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay. Journal of Ethnopharmacology. ,vol. 100, pp. 210- 215 ,(2005) , 10.1016/J.JEP.2005.04.004
Ola Bergendorff, Kim Dekermendjian, Mogens Nielsen, Rudong Shan, Robin Witt, Jinglu Ai, Olov Sterner, Furanocoumarins with affinity to brain benzodiazepine receptors in vitro Phytochemistry. ,vol. 44, pp. 1121- 1124 ,(1997) , 10.1016/S0031-9422(96)00703-0
Kenneth J. Sufka, J. Todd Roach, Walter G. Chambliss Jr, Susan L. Broom, Matt W. Feltenstein, Christy M. Wyandt, Lu Zeng, Anxiolytic properties of botanical extracts in the chick social separation-stress procedure Psychopharmacology. ,vol. 153, pp. 219- 224 ,(2001) , 10.1007/S002130000571
H. Viola, C. Wolfman, M.Levi de Stein, C. Wasowski, C. Peña, J.H. Medina, A.C. Paladini, Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae). Journal of Ethnopharmacology. ,vol. 44, pp. 47- 53 ,(1994) , 10.1016/0378-8741(94)90098-1