Ocular Levels of Azithromycin
作者： Khalid F Tabbara , Soliman A Al-Kharashi , Samir M Al-Mansouri , Othman M Al-Omar , Hendrik Cooper
DOI: 10.1001/ARCHOPHT.116.12.1625
关键词: Antibiotics 、 Biopsy 、 Internal medicine 、 Trachoma 、 Antibacterial agent 、 Azithromycin 、 Oral administration 、 Chlamydia trachomatis 、 Minimum inhibitory concentration 、 Medicine 、 Gastroenterology 、 Pathology 、 Ophthalmology
摘要: Objective To assess azithromycin levels in human serum, aqueous humor, tear fluid, and conjunctival tissue specimens after administration of a single 1-g oral dose azithromycin. Methods Sixty patients undergoing cataract surgery were included this analysis. Serum, aqueous, collected 3, 6, 12 hours 1, 2, 4 days administration. Conjunctival biopsy 4, 8, 10, 12, 14 All subjected to analysis by high-performance liquid chromatography–mass spectrometry. Results Azithromycin concentration ranges during the specified sampling times as follows: 21 974 ng/mL; tear, 82 2892 10 69 conjunctival, 0.7 32 µg/g. Levels above 90% minimal inhibitory (MIC 90 ) for Chlamydia trachomatis detected all samples following Conclusion We demonstrated prolonged high drug-targeted ocular tissue. Prolonged concentrations make drug suitable treatment conjunctivitis caused chlamydiae other susceptible organisms.
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