Clotting Factor Deficiency in Early Trauma-Associated Coagulopathy
作者： Sandro B. Rizoli , Sandro Scarpelini , Jeannie Callum , Bartolomeu Nascimento , Kenneth G. Mann
DOI: 10.1097/TA.0B013E318232E5AB
关键词: Gastroenterology 、 Coagulopathy 、 Surgery 、 Medicine 、 Internal medicine 、 Prothrombin time 、 Clotting factor 、 Injury Severity Score 、 Prospective cohort study 、 Protein C 、 Coagulation Protein Disorders 、 Fresh frozen plasma
摘要: Background Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma to trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CF). This may dramatically improve survival patients. However, other studies suggest that TAC occurs protein C activation independent CF deficiency. The present study investigated whether deficiency associated with coagulopathy.
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