Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing.
作者： Guopu Chen , Yunru Yu , Xiuwen Wu , Gefei Wang , Guosheng Gu
关键词: Absorption (skin) 、 Zinc 、 Metal-organic framework 、 Superoxide dismutase 、 Wound healing 、 Membrane 、 Chemical engineering 、 Niacin 、 Chemistry 、 Metal ions in aqueous solution
摘要: Niacin metal-organic frameworks (MOFs) encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfluidic electrospray approach for wound healing. As the bacteria-responsively degradable, niacin MOFs could intelligently, controllably, programmably release calcium, copper, zinc ions, depending on degree of infections. The released ions not only kill microbes destroying their membrane inducing outflow nutrient substance, but also activate copper/zinc superoxide dismutase (Cu/Zn-SOD) to eliminate oxygen free radicals rescue cells from oxidative stress injury. Furthermore, simultaneously promote hemangiectasis absorption functional metal ions. Thus, imparted outstanding antibacterial, antioxidant, angiogenesis properties. Based an vivo study, we have demonstrated that chronic healing process infected full-thickness skin defect model be significantly enhanced as therapeutic agent. Therefore, are potential clinical applications.
sciencemag.org参考文章(37)
Donald R. Griffin, Westbrook M. Weaver, Philip O. Scumpia, Dino Di Carlo, Tatiana Segura, Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks Nature Materials. ,vol. 14, pp. 737- 744 ,(2015) , 10.1038/NMAT4294
Nicolas Vita, Semeli Platsaki, Arnaud Baslé, Stephen J. Allen, Neil G. Paterson, Andrew T. Crombie, J. Colin Murrell, Kevin J. Waldron, Christopher Dennison, A four-helix bundle stores copper for methane oxidation Nature. ,vol. 525, pp. 140- 143 ,(2015) , 10.1038/NATURE14854
Matthew Y. H. Tang, Ho Cheung Shum, One-step immunoassay of C-reactive protein using droplet microfluidics Lab on a Chip. ,vol. 16, pp. 4359- 4365 ,(2016) , 10.1039/C6LC01121G
I. Weinrauch, I. Savchenko, D. Denysenko, S. M. Souliou, H-H Kim, M. Le Tacon, L. L. Daemen, Y. Cheng, A. Mavrandonakis, A. J. Ramirez-Cuesta, D. Volkmer, G. Schütz, M. Hirscher, T. Heine, Capture of heavy hydrogen isotopes in a metal-organic framework with active Cu(I) sites Nature Communications. ,vol. 8, pp. 14496- 14496 ,(2017) , 10.1038/NCOMMS14496
Yunru Yu, Fanfan Fu, Luoran Shang, Yao Cheng, Zhongze Gu, Yuanjin Zhao, Bioinspired Helical Microfibers from Microfluidics Advanced Materials. ,vol. 29, pp. 1605765- ,(2017) , 10.1002/ADMA.201605765
Luoran Shang, Yao Cheng, Yuanjin Zhao, Emerging Droplet Microfluidics Chemical Reviews. ,vol. 117, pp. 7964- 8040 ,(2017) , 10.1021/ACS.CHEMREV.6B00848
Fanfan Fu, Zhuoyue Chen, Ze Zhao, Huan Wang, Luoran Shang, Zhongze Gu, Yuanjin Zhao, Bio-inspired self-healing structural color hydrogel Proceedings of the National Academy of Sciences of the United States of America. ,vol. 114, pp. 5900- 5905 ,(2017) , 10.1073/PNAS.1703616114
Yu Shrike Zhang, Chunlei Zhu, Younan Xia, Inverse Opal Scaffolds and Their Biomedical Applications. Advanced Materials. ,vol. 29, pp. 1701115- ,(2017) , 10.1002/ADMA.201701115
Jie Wang, Minhan Zou, Lingyu Sun, Yao Cheng, Luoran Shang, Fanfan Fu, Yuanjin Zhao, Microfluidic generation of Buddha beads-like microcarriers for cell culture Science China Materials. ,vol. 60, pp. 857- 865 ,(2017) , 10.1007/S40843-017-9081-5
A. Knebel, B. Geppert, K. Volgmann, D. I. Kolokolov, A. G. Stepanov, J. Twiefel, P. Heitjans, D. Volkmer, J. Caro, Defibrillation of soft porous metal-organic frameworks with electric fields. Science. ,vol. 358, pp. 347- 351 ,(2017) , 10.1126/SCIENCE.AAL2456