Pyruvate and related α-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity
作者： Ulrich Andrae , Jaswanth Singh , Kyriakoula Ziegler-Skylakakis
DOI: 10.1016/0378-4274(85)90015-3
关键词: Cytotoxicity 、 Chinese hamster 、 Hydrogen peroxide 、 Biology 、 In vitro 、 Biochemistry 、 In vivo 、 α ketoacids 、 Eagle's minimal essential medium 、 Antioxidant
摘要: Abstract Pyruvate efficiently protected V79 Chinese hamster cells against the lethal effects of hydrogen peroxide. Protection was also provided by other α-ketoacids, such as α-ketobutyrate, α-ketoglutarate and α-ketoadipate, although higher concentrations were required. The corresponding β-ketoacids had no effect. results indicate that pyruvate α-ketoacids possess antioxidant activity in vitro and, probably, vivo.
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