Light energized tissue adhesive

摘要: Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) 800 (80%) protein. In particular, Type I collagen, example, first prepared by extraction bovine porcine hide purified. preparations then sulfhydryl reagents improve cohesive strength secondary derivatizing agents, such as carboxyl groups, solder tissue. formed into viscous solutions, gels solid films, when exposed energy generated infrared laser, undergo thermally induced phase transitions. Solid semi-solid protein become less enabling high concentration penetrate interstices treated fill voids in As thermal released surrounding environment, again semi-solid, adhering space.