Differential aging of the human striatum: longitudinal evidence.

摘要: BACKGROUND AND PURPOSE: Information about age-related changes in the striatum comes almost exclusively from cross-sectional studies. We examined differences and longitudinal volume of striatal nuclei, compared measures with their estimates, addressed question differential aging basal ganglia. METHODS: measured volumes caudate nucleus (head), putamen, globus pallidus on MR images 53 healthy adults whose ages at baseline ranged between 20 77 years. The measurements were conducted twice, 5 years apart. RESULTS: On both measurement occasions, neostriatal nuclei (caudate putamen) but not correlated negatively age. However, comparison revealed significant declines smaller (but statistically significant) shrinkage paleostriatum. In years, components (caudate, pallidus) shrunk by 1.21, 0.85, 0.55 standard deviation units, respectively. average annual rate was 0.83% nucleus, 0.73% 0.51% pallidus. CONCLUSION: Although estimates suggested preservation some whole evident even a selected group adults. Moreover, magnitude observed change greater than predicted