Physiological changes during prolonged seizures and epileptic brain damage.

摘要: The role of physiological changes occurring during prolonged seizures in the causation epileptic brain damage has been investigated experimentally baboons and rats. Prolonged drug-induced myoclonic seizure activity is associated with initial arterial hypertension subsequent hypotension, increased venous pressure, early hyperglycaemia hypoglycaemia, variable hypoxia lactacidosis, hyperpyrexia. Cerebral metabolic rate for oxygen glucose 2--3 fold throughout provided status animal well maintained. Ischaemic neuronal change found after lasting 1.5--7 hours, involving small neurones third cortical lamina, Purkinje basket cells cerebellum, pyramidal neurons endfolium Sommer sector hippocampus. Muscular paralysis artificial ventilation minimise late such as hypotension hyperpyrexia, protect against cerebellar damage, but only slightly neocortical hippocampal damage. When or hypoglycaemia lead to a reduction intensity discharge paralysed, ventilated rats, there also Factors intimately related duration are responsible lesions.