Effects of several endothelin receptor antagonists on gastrointestinal transit of guinea pigs.
作者： Kenichi Kuwahara , Yoshio Kitsukawa , Yasuo Suzuki , Yasushi Saito
关键词: Small intestine 、 Gastric emptying 、 Gastrointestinal tract 、 Bosentan 、 Cecum 、 Internal medicine 、 Stomach 、 Biology 、 Gastroenterology 、 Endothelin receptor 、 Guinea pig
摘要: This study was undertaken to investigate the effects of endothelinA receptor antagonist (ETA-RA) BQ485; ETB-RA BQ788, and nonselective ETA/B-RA Bosentan on gastrointestinal transit guinea pigs. We further analyzed distribution ET-R subtypes smooth muscle cells (SMC) tract their direct involvement SMC in transit. A pig model used measure intestinal The (100 mg/kg, per os), BQ485 (1 intraperitoneally) BQ788 stomach, small intestine, colon were evaluated. separated from cecum, by collagenase each part binding assay. Gastric significantly inhibited BQ485, Bosentan. Small not affected any these agents. ETA-R ETB-R widely distributed colon. ratio 1:3 but 1:10 total number 1:3:9:1. These results indicate that both are strongly involved stomach However, discrepancy between various antagonists suggests is directly
springer.com
sci-hub.se 参考文章(38)
H.T. Haigler, F.R. Maxfield, M.C. Willingham, I. Pastan, Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. Journal of Biological Chemistry. ,vol. 255, pp. 1239- 1241 ,(1980) , 10.1016/S0021-9258(19)86019-2
E.R. Martin, B.M. Brenner, B.J. Ballermann, Heterogeneity of cell surface endothelin receptors. Journal of Biological Chemistry. ,vol. 265, pp. 14044- 14049 ,(1990) , 10.1016/S0021-9258(18)77454-1
Hiroshi Inagaki, Anne E. Bishop, Cesar Escrig, John Wharton, Timothy G. Allen-Mersh, Julia M. Polak, Localization of endothelinlike immunoreactivity and endothelin binding sites in human colon Gastroenterology. ,vol. 101, pp. 47- 54 ,(1991) , 10.1016/0016-5085(91)90458-W
Kohtaro Taniyama, Isamu Sano, Shinji Nakayama, Shogo Matsuyama, Koichiro Takeda, Chika Yoshihara, Chikako Tanaka, Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors. Gastroenterology. ,vol. 101, pp. 1579- 1587 ,(1991) , 10.1016/0016-5085(91)90395-2
Iris Schvartz, Olivia Ittoop, Eli Hazum, Direct evidence for multiple endothelin receptors. Biochemistry. ,vol. 30, pp. 5325- 5327 ,(1991) , 10.1021/BI00235A028
T. Fukuroda, T. Fujikawa, S. Ozaki, K. Ishikawa, M. Yano, M. Nishikibe, Clearance of Circulating Endothelin-1 by ETB Receptors in Rats Biochemical and Biophysical Research Communications. ,vol. 199, pp. 1461- 1465 ,(1994) , 10.1006/BBRC.1994.1395
H. Y. Lin, E. H. Kaji, G. K. Winkel, H. E. Ives, H. F. Lodish, Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 3185- 3189 ,(1991) , 10.1073/PNAS.88.8.3185
A. Inoue, M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto, T. Masaki, The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 2863- 2867 ,(1989) , 10.1073/PNAS.86.8.2863
Christian Frelin, Annie Ladoux, Robert Marsault, Paul Vigne, Functional properties of high- and low-affinity receptor subtypes for endothelin-3. Journal of Cardiovascular Pharmacology. ,vol. 17, ,(1991) , 10.1097/00005344-199100177-00035
A. Giaid, S. J. Gibson, B. N. Ibrahim, S. Legon, S. R. Bloom, M. Yanagisawa, T. Masaki, I. M. Varndell, J. M. Polak, Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 7634- 7638 ,(1989) , 10.1073/PNAS.86.19.7634