Delayed Onset of Malaria — Implications for Chemoprophylaxis in Travelers

摘要: Background Most antimalarial agents used by travelers act on the parasite's blood stage and therefore do not prevent late-onset illness, particularly that due to species cause relapsing malaria. We examined magnitude of this problem among Israeli American travelers. Methods malaria surveillance data from Israel United States determine traveler's destination, infecting species, type chemoprophylaxis used, incubation period. Results In Israel, 1994 through 1999, there were 300 cases returning in which one plasmodium could be identified. 134 these (44.7 percent), illness developed more than two months after return; nearly all infection with Plasmodium vivax or P. ovale. 108 (80.6 patient had an regimen according national guidelines. States, 1992 1998, 2822 cas...