The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection.
作者： Navkiran Gill , Elizabeth J. Davies , Ali A. Ashkar
DOI: 10.1111/J.1600-0897.2007.00558.X
关键词: Viral replication 、 Biology 、 Innate immune system 、 Human immunodeficiency virus (HIV) 、 Toll-like receptor 、 Immunology 、 Receptor 、 Virology 、 Genital hsv 、 Increased risk 、 Herpes simplex virus
摘要: Control of virus replication initially depends on rapid activation the innate immune responses. Toll-like receptor (TLR) ligands are potent inducers immunity against viral infections, including herpes simplex (HSV). HSV-2 is currently one most common sexually transmitted infections in developed nations and becoming more prevalent adolescents. infects genital mucosa associated with an increased risk obtaining other such as HIV. There no vaccine available HSV-2. In last several years, there has been interest utilizing to initiate responses order provide early line defence replication. This review highlights recent studies investigating effect various TLR infection. A considerable body information published local delivery mucosa. We have outlined that a potential protection addition, we presented possible mechanisms by which provides
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