Effect of Abrus precatorius L. on Experimental Tumors

摘要: Summary A protein extract isolated from the seeds of Abrus precatorius L. is shown to exhibit antitumor activity on Yoshida sarcoma (solid and ascites forms) in rats a fibrosarcoma mice. The intraperitoneal route administration more effective than subcutaneous injections. has direct cytotoxic effect tumor cells. Vacuolation disruption cytoplasm accompanied by karyolysis chromosomal abnormalities are seen cells treated with vivo . This also confirmed vitro studies. incubated showed cellular pathology, decreased viable cell counts, prolongation survival period tumor-transplanted animals.