Structurally diverse terpenoids with neuroprotective activities from the resins of Populus euphratica.
作者： Yun-Yun Liu , Fu-Ying Qin , Tian-Chang He , Yi-Ping Xiong , Yong-Ming Yan
DOI: 10.1016/J.FITOTE.2020.104560
关键词: Stereochemistry 、 Abietane 、 Neuroprotection 、 Terpenoid 、 Populus euphratica 、 Chemistry
摘要: Abstract Five new terpenoids including one abietane diterpenoid (1), aromadendrane (6), two norsesquiterpenoids (8 and 9), a cembrane-derived (12), together with seven known compounds were isolated from Populus euphratica resins. The structures of these compounds, their absolute configurations, characterized by spectroscopic computational methods. All the except 8 test for neuroprotective activities. result revealed that 1, 7, 10–12 display activities in glutamate-induced SH-SY5Y cells concentration-dependent manner.
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