Chapter 5 Amphibian Alkaloids
作者： Bernhard Witkop , Edda Gössinger
DOI: 10.1016/S0099-9598(08)60051-6
关键词: Binding site 、 Tetrodotoxin 、 Biology 、 Stereochemistry 、 Batrachotoxin 、 Sodium channel 、 Veratridine 、 Receptor 、 Saxitoxin 、 Neurotoxin 、 Biochemistry
摘要: Publisher Summary This chapter describes the novel amphibian toxins, their isolation, structure, and syntheses, phenomenon of receptors that selectively bind to specific agents. The also discusses location function amphibious venoms; spiropiperidines, cis -decahydroquinolines, octahydroindolizidines; neurotoxins, receptors, ion transport. Amphibian venoms may offer only some passive protection. are located in skin glands, cases eggs species, very rarely bloodstream. Tetrodotoxin saxitoxin at receptor site 1 block transport activity sodium channel. steroidal alkaloids batrachotoxin and, a lesser degree, veratridine terpinoids aconitine grayanotoxin, 2, common binding probably channel, belonging subunit exercising control over other subunits must interact for various functions Batrachotoxin is most useful probe biochemical studies neurotoxin 2 on
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