TSH Regulation Dynamics in Central and Extreme Primary Hypothyroidism

摘要: Background: Thyrotropin (TSH) changes in extreme primary hypothyroidism include increased secretion, slowed degradation, and diminished or absent TSH circadian rhythms. Diminished rhythms are also observed central hypothyroid patients have been speculated to be a cause of hypothyroidism. We examined whether secretion saturation, previously suggested hypothyroidism, might explain both disorders. Methods: augmented extended the range our published feedback control system model reflect nonlinear including putative quantified validated it using multiple clinical datasets ranging from euthyroid (postthyroidectomy). simulated by reducing overall normal without oscillation, maintaining plasma at constant levels. utilized validat...