Instant Cirrhosis: An Improved Method for Producing Cirrhosis of the Liver in Rats by Simultaneous Administration of Carbon Tetrachloride and Phenobarbitone

摘要: An improved method for production of cirrhosis the liver in rats is described. Rats are given CCl4 and phenobarbitone simultaneously. The doubles yield cirrhotic animals halves time taken their production, comparison with alone. CCl4 inhalation results fewer intercurrent deaths than oral dosing CCl4. as observed histologically accompanied by gross nodularity liver, splenomegaly, portal hypertension testicular atrophy. About 50 per cent have measurable ascites. Animals killed during application new show that develops only after 4 weeks dosage.