Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia.
作者： Margaret Nieborowska-Skorska , Silvia Maifrede , Min Ye , Monika Toma , Elizabeth Hewlett
DOI: 10.1080/10428194.2018.1520988
关键词: Chemistry 、 PARP1 、 Cell culture 、 Poly ADP ribose polymerase 、 DNA repair 、 Cancer cell 、 Cancer research 、 Leukemia 、 NAD+ kinase 、 DNA damage
摘要: Tumor cells accumulate spontaneous and drug-induced DNA damage, but they survive because of enhanced/altered repair activities [1]. The hypothesis that cancer are addicted to particular D...
sci-hub.se 参考文章(15)
Fatima Dkhissi, Djamel Aggoune, Julien Pontis, Nathalie Sorel, Nathalie Piccirilli, Amélie LeCorf, François Guilhot, Jean-Claude Chomel, Slimane Ait-Si-Ali, Ali G. Turhan, The downregulation of BAP1 expression by BCR-ABL reduces the stability of BRCA1 in chronic myeloid leukemia. Experimental Hematology. ,vol. 43, pp. 775- 780 ,(2015) , 10.1016/J.EXPHEM.2015.04.013
Bryan K. Slinker, The Statistics of Synergism Journal of Molecular and Cellular Cardiology. ,vol. 30, pp. 723- 731 ,(1998) , 10.1006/JMCC.1998.0655
Christopher J Lord, Alan Ashworth, Mechanisms of resistance to therapies targeting BRCA-mutant cancers Nature Medicine. ,vol. 19, pp. 1381- 1388 ,(2013) , 10.1038/NM.3369
Alexander W. Bird, David Y. Yu, Marilyn G. Pray-Grant, Qifeng Qiu, Kirsty E. Harmon, Paul C. Megee, Patrick A. Grant, M. Mitchell Smith, Michael F. Christman, Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair Nature. ,vol. 419, pp. 411- 415 ,(2002) , 10.1038/NATURE01035
Jirina Bartkova, Zuzana Hořejší, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas, Jiri Bartek, DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature. ,vol. 434, pp. 864- 870 ,(2005) , 10.1038/NATURE03482
Paulina Podszywalow-Bartnicka, Magdalena Wolczyk, Monika Kusio-Kobialka, Kamila Wolanin, Krzysztof Skowronek, Margaret Nieborowska-Skorska, Yashodhara Dasgupta, Tomasz Skorski, Katarzyna Piwocka, Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation Cell Cycle. ,vol. 13, pp. 3727- 3741 ,(2014) , 10.4161/15384101.2014.965013
Junko Murai, Shar-yin N. Huang, Benu Brata Das, Amelie Renaud, Yiping Zhang, James H. Doroshow, Jiuping Ji, Shunichi Takeda, Yves Pommier, Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors Cancer Research. ,vol. 72, pp. 5588- 5599 ,(2012) , 10.1158/0008-5472.CAN-12-2753
Christopher J. Lord, Andrew N.J. Tutt, Alan Ashworth, Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors Annual Review of Medicine. ,vol. 66, pp. 455- 470 ,(2015) , 10.1146/ANNUREV-MED-050913-022545
Colin J. Thomas, Elena Kotova, Mark Andrake, Jared Adolf-Bryfogle, Robert Glaser, Catherine Regnard, Alexei V. Tulin, Kinase-Mediated Changes in Nucleosome Conformation Trigger Chromatin Decondensation via Poly(ADP-Ribosyl)ation Molecular Cell. ,vol. 53, pp. 831- 842 ,(2014) , 10.1016/J.MOLCEL.2014.01.005
Ketki Karanam, Ran Kafri, Alexander Loewer, Galit Lahav, Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid-S phase Molecular Cell. ,vol. 47, pp. 320- 329 ,(2012) , 10.1016/J.MOLCEL.2012.05.052