MYC overexpression correlates withMYCamplification or translocation, and is associated with poor prognosis in mantle cell lymphoma

作者: Ji-Young Choe , Ji Yun Yun , Hee Young Na , Jooryung Huh , Su-Jin Shin

DOI: 10.1111/HIS.12760

关键词: MYC Gene AmplificationChromosomal translocationMantle cell lymphomaImmunohistochemistryClinical significanceMYC AmplificationBiologyPathogenesisBlastoidMolecular biologyCancer research

摘要: Aims We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), the clinical significance of these factors. Methods results Sixty-five patients with MCL, including 54 classic, nine blastoid two pleomorphic variants, were enrolled. Expression MYC, Ki67 p53 was assessed by immunohistochemistry. amplification or translocation examined fluorescence in-situ hybridization. higher blastoid/pleomorphic MCL variants (mean, 19.0%) than classic 1.9%; P < 0.001). also significantly variants. found 53 cases tested, both which high (29.7% 20.4%). 52 remarkably (68.5% 71.0%). High associated shortened overall survival progression-free univariable multivariable analyses (all P < 0.05). Conclusions MYC overexpression is a negative predictor patient outcomes. gene might be related pathogenesis particularly

参考文章(16)
Lynn C Moscinski, Elizabeth M Sagatys, Haipeng Shao, Stuart Schwartz, Peter Papenhausen, Reza Setoodeh, Ling Zhang, Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature. International Journal of Clinical and Experimental Pathology. ,vol. 6, pp. 155- 167 ,(2013)
Karen M. Chisholm, Charles D. Bangs, Carlos E. Bacchi, Hernan Molina- Kirsch, Athena Cherry, Yasodha Natkunam, Expression profiles of MYC protein and MYC gene rearrangement in lymphomas. The American Journal of Surgical Pathology. ,vol. 39, pp. 294- 303 ,(2015) , 10.1097/PAS.0000000000000365
Audrey Delas, Dobbelstein Sophie, Pierre Brousset, Camille Laurent, Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature. Pathology Research and Practice. ,vol. 209, pp. 115- 119 ,(2013) , 10.1016/J.PRP.2012.12.001
Matthew J Oberley, Saurabh A Rajguru, Chong Zhang, KyungMann Kim, Gene R Shaw, Kreg M Grindle, Brad S Kahl, Craig Kanugh, Jennifer Laffin, David T Yang, Immunohistochemical evaluation of MYC expression in mantle cell lymphoma. Histopathology. ,vol. 63, pp. 499- 508 ,(2013) , 10.1111/HIS.12207
H. Mossafa, D. Damotte, A. Jenabian, R. Delarue, A. Vincenneau, I. Amouroux, R. Jeandel, E. Khoury, J. M. Martelli, T. Samson, S. Tapia, G. Flandrin, X. Troussard, Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis Leukemia & Lymphoma. ,vol. 47, pp. 1885- 1893 ,(2006) , 10.1080/10428190600687547
Cristina Royo, Itziar Salaverria, Elena M. Hartmann, Andreas Rosenwald, Elías Campo, Sílvia Beà, The complex landscape of genetic alterations in mantle cell lymphoma. Seminars in Cancer Biology. ,vol. 21, pp. 322- 334 ,(2011) , 10.1016/J.SEMCANCER.2011.09.007
Tomasz Sewastianik, Monika Prochorec-Sobieszek, Bjoern Chapuy, Przemysław Juszczyński, MYC deregulation in lymphoid tumors: molecular mechanisms, clinical consequences and therapeutic implications Biochimica et Biophysica Acta. ,vol. 1846, pp. 457- 467 ,(2014) , 10.1016/J.BBCAN.2014.08.006
Lena Nordström, Sandra Sernbo, Patrik Eden, Kirsten Grønbæk, Arne Kolstad, Riikka Räty, Marja‐Liisa Karjalainen, Christian Geisler, Elisabeth Ralfkiær, Christer Sundström, Anna Laurell, Jan Delabie, Mats Ehinger, Mats Jerkeman, Sara Ek, SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma--a Nordic Lymphoma Group study. British Journal of Haematology. ,vol. 166, pp. 98- 108 ,(2014) , 10.1111/BJH.12854
German Ott, Andreas Rosenwald, Elias Campo, Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification. Blood. ,vol. 122, pp. 3884- 3891 ,(2013) , 10.1182/BLOOD-2013-05-498329
Sonali M. Smith, John Anastasi, Kenneth S. Cohen, Lucy A. Godley, The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma. Blood Cells Molecules and Diseases. ,vol. 45, pp. 317- 323 ,(2010) , 10.1016/J.BCMD.2010.08.002