作者: Ji-Young Choe , Ji Yun Yun , Hee Young Na , Jooryung Huh , Su-Jin Shin
DOI: 10.1111/HIS.12760
关键词: MYC Gene Amplification 、 Chromosomal translocation 、 Mantle cell lymphoma 、 Immunohistochemistry 、 Clinical significance 、 MYC Amplification 、 Biology 、 Pathogenesis 、 Blastoid 、 Molecular biology 、 Cancer research
摘要: Aims We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), the clinical significance of these factors. Methods results Sixty-five patients with MCL, including 54 classic, nine blastoid two pleomorphic variants, were enrolled. Expression MYC, Ki67 p53 was assessed by immunohistochemistry. amplification or translocation examined fluorescence in-situ hybridization. higher blastoid/pleomorphic MCL variants (mean, 19.0%) than classic 1.9%; P < 0.001). also significantly variants. found 53 cases tested, both which high (29.7% 20.4%). 52 remarkably (68.5% 71.0%). High associated shortened overall survival progression-free univariable multivariable analyses (all P < 0.05). Conclusions MYC overexpression is a negative predictor patient outcomes. gene might be related pathogenesis particularly