Strain differences in the antitumor activity of an immunopotentiator, Nocardia rubra cell-wall skeleton, in B10 congenic and recombinant mice.

摘要: An immunogenetic evaluation of the antitumor activity immunopotentiator Nocardia rubra cell-wall skeleton (N. rubra-CWS) has been performed using non-virus-producing tumors induced by Schmidt-Ruppin strain Rous sarcoma virus (RSV) in B10 congenic and recombinant mice. Live tumor cells mixed with either N. rubra-CWS or a placebo control were inoculated intradermally into right flank syngeneic With rubra-CWS, development growth mouse tumors, S1018(B10) B10SA2F, B10(H-2b) mice completely inhibited all test B10.A(5R) tumor, S322(5R), was suppressed 23 25 B10.A(5R)(H-2i5) mice, B10.BR S623(BR), 7 14 B10.BR(H-2k) However, B10.D2 S908(D2), B10.D2(H-2d) B10.A S826(BA) B10ABr1F, B10.A(H-2a) not at rubra-CWS. showed remarkable effect only inoculation but also intratumoral administration. These effects seen Peritoneal exudate (PEC) from strains previously treated intraperitoneally and/or MMC-treated cytolytic cytostatic activities on derived both strains. results did reflect difference vivo studies. Mitogenic spleen cells, however, significantly different among mice; greater blastogenesis than those corresponding to showing difference. suggest that host's background may play an important role cancer therapy immunopotentiators.