From Gleason to International Society of Urological Pathology (ISUP) grading of prostate cancer

摘要: Gleason grading of prostate cancer has gained worldwide acceptance since its introduction 50 years ago. This system fulfilled the role a powerful prognostic indicator for many and this influenced treatment. There have been numerous changes to management diagnosis 1966, including prostate-specific antigen screening, resulting in early detection cancer, resulted evolution with informal adoption number alterations. Significant were made 2005 through consensus conference convened by International Society Urological Pathology (ISUP). In more recent times, necessity further apparent follow-up ISUP was held 2014. Changes from included classifying all cribriform glomeruloid patterns as grade 4, mucinous adenocarcinoma based on underlying architecture rather than uniformly considering these tumors pattern score (GS)-based 5 system, which incorporated 2014 modifications system. Designated grade, consists five grades: 1 (GS ≤3 + 3), 2 3 + 4), 3 4 + 3), 4 4 + 4, 3 + 5, 5 + 3) 9-10). With advances recently reported literature, it is that amendments current are likely be necessary future.