ASSOCIATION OF THE 5-HTTLPR WITH PROLACTIN RESPONSE TO CITALOPRAM IN A COMMUNITY POPULATION

摘要: ASSOCIATION OF THE 5-HTTLPR WITHPROLACTIN RESPONSE TO CITALOPRAMIN A COMMUNITY POPULATIONEloise Peet, BSUniversity of Pittsburgh, 2004The serotonin transporter (5-HTT) is a key mechanism regulating magnitude and duration serotonergic transmission in the central nervous system, site action selective reuptake inhibitors (SSRIs) used for treating psychiatric conditions. Variation treatment response to SSRIs has been correlated with common bi-allelic length polymorphism 5-HTT-promoter region (5-HTTLPR), known modulate transcriptional efficiency 5-HTT gene vitro. The alleles, designated long (l) or short (s), result one three possible genotypes: l/l, l/s, s/s. (s) allele hypothesized have dominant functional effect, associated decreased transcription poorer therapeutic antidepressants. Acute blockade rapidly increases system levels, leading hypothalamic receptor stimulation release several hormones, including prolactin. specific aim this study characterize prolactin acute 5-HTT-reuptake according genotype, further elucidate effect on function vivo. This designed test hypothesis that, when compared subjects l/l either s/l s/s genotype will experience blunted following administration highly inhibitor Citalopram. To accomplish goal, cohort 206 community volunteers were intravenously administered weight-adjusted dose Each subject was genotyped 5-HTTLPR, blood samples obtained Citalopram levels immediately before at regular intervals 2.5 hours after injection. Results: Citalopram-induced response, reported as area under curve (PRL AUC), significantly (F = 3.08, p 0.048). Among individuals PRL AUC (M±SD: 84.2 ± 51.8 ng/ml * 150min) lower (p 0.014) than group (246.0 40.2 150 min). difference between l/s (172.5 41.3 min) not significant 0.21); also 0.23). When results analyzed maximum change prolactin, MAX similarly 0.034). Conclusions: Subjects exhibit SSRI carrying two copies l allele. s does non-patient population.