Utilizing Fibronectin Integrin-Binding Specificity to Control Cellular Responses.
作者： Haylee Bachman , John Nicosia , Marilyn Dysart , Thomas H. Barker
关键词: Integrin 、 Fibronectin 、 Epithelial–mesenchymal transition 、 Cell biology 、 Integrin binding 、 Tissue engineering 、 Chemistry 、 Morphogenesis 、 Bioinformatics 、 Extracellular matrix 、 Wound healing
摘要: Significance: Cells communicate with the extracellular matrix (ECM) protein fibronectin (Fn) through integrin receptors on cell surface. Controlling integrin-Fn interactions offers a promising approach to directing behavior, such as adhesion, migration, and differentiation, well coordinated tissue behaviors morphogenesis wound healing. Recent Advances: Several different groups have developed recombinant fragments of Fn that can control epithelial mesenchymal transition, sequester growth factors, promote bone It is thought these physiological responses are, in part, due specific engagement. Furthermore, it has been postulated integrin-binding domain mechanically sensitive switch drives binding one heterodimer over another. Critical Issues: Although computational simulations predicted mechano-switch hypothesis recent evidence supports existence varying strain states vivo, experimental still lacking. Future Directions: Evidence will enable development new Fn-based peptides engineering healing, deepen our understanding ECM pathologies, fibrosis.
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