Differential effects of acute and sustained cyclosporine and tacrolimus on sympathetic nerve activity.
作者： Inge HHT Klein , Alferso C Abrahams , Thomas van Ede , P Liam Oey , Gerry Ligtenberg
DOI: 10.1097/HJH.0B013E32833C20EB
关键词: Tacrolimus 、 Ciclosporin 、 Endocrinology 、 Sympathetic nervous system 、 Medicine 、 Blood pressure 、 Rostral ventrolateral medulla 、 Calcineurin 、 Internal medicine 、 Plasma renin activity 、 Heart transplantation
摘要: Background We studied the effect of acute and sustained cyclosporine tacrolimus on muscle sympathetic nerve activity (MSNA) in groups healthy male volunteers. Methods results Acute normal dose (2.5 mg/kg) increased MSNA from 11 +/- 6 to 19 8 bursts/min (P Conclusion Sympathetic overactivity plays a role hypertensive action cyclosporine. Cyclosporine given during 2 weeks increases blood pressure suppresses MSNA, possibly by volume retention. Tacrolimus, presently applied dosages, does not cause hypertension or overactivity. However, also activity, reason which is unclear. J Hypertens 28:1928-1934 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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