Drug–Herb and Drug–Food Interactions

摘要: Interactions between herbal supplements and drugs food are of significant clinical importance. St. John’s wort, a popular supplement, induces cytochrome P 450 mixed function oxidase as well modulated P-glycoprotein in intestine reduces plasma concentrations cyclosporine, tacrolimus, amitriptyline, digoxin, fexofenadine, indinavir, methadone, midazolam, nevirapine, phenoprocoumon, squinavir, simvastatin, theophylline warfarin. These reductions may cause treatment failures. Interaction warfarin with increase or decrease the anticoagulant effect Important interactions various ginseng, ginkgo biloba, kava garlic have also been reported. Consumption single glass grapefruit juice caused twofold to threefold concentration felodipine, pharmocokinetics approximately 40 other affected by intake juice. In contrast, bioavailability fexofinadine was significantly reduced Orange, cranberry, pomelo pomegranate alter certain drugs. piperine, constituent black pepper drugs,