Review Article Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms
作者： Ling Lin , Kebin Hu
DOI:
关键词: Phenotype 、 Review article 、 Cytokine 、 Serine protease 、 Cell biology 、 Inflammation 、 Gene 、 Proinflammatory cytokine 、 Biology 、 Tissue plasminogen activator
摘要: In disease conditions, inflammatory cells, such as neutrophils, T and monocytes/macrophages, are recruited in response to injury cues express panoply of proinflammatory genes through a combination tran - scription factors. Tissue plasminogen activator (tPA), member the serine protease family, has been shown act cytokine activate profound receptor-mediated signaling events. this review, we will discuss role tPA inflammation various models, illuminate its mechanisms underlying modulation inflammation.
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