UFP-112 a potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor
作者： Girolamo Calo' , Anna Rizzi , Carlo Cifani , Maria Vittoria Micioni Di Bonaventura , Domenico Regoli
DOI: 10.1111/J.1755-5949.2009.00107.X
关键词: In vitro 、 Peptide sequence 、 Nociceptin receptor 、 Agonist 、 Chemistry 、 Peptide 、 In vivo 、 Receptor 、 Pharmacology 、 NOP
摘要: Nociceptin/orphanin FQ (N/OFQ) controls several biological functions via selective activation of the N/OFQ peptide receptor (NOP). [(pF)Phe4Aib7Arg14Lys15]N/OFQ-NH2 (UFP-112) is an NOP ligand designed using a combination chemical modifications in same sequence that increase affinity/potency and/or reduce susceptibility to enzymatic degradation. In present review article, we summarize data from literature and original findings on vitro vivo pharmacological features UFP-112. Moreover, important actions possible therapeutic indications agonists are discussed based results obtained with UFP-112 compared other nonpeptide ligands.
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sci-hub.se 参考文章(158)
E Schlicker, B Malinowska, G Godlewski, Function of nociceptin and opioid OP4 receptors in the regulation of the cardiovascular system. Journal of Physiology and Pharmacology. ,vol. 53, pp. 301- 324 ,(2002)
Thomas C. Gasser, In Vitro Studies Fortschritte der Urologie und Nephrologie. pp. 12- 12 ,(1992) , 10.1007/978-3-642-85422-4_3
Matteo Marti, Flora Mela, Remo Guerrini, Girolamo Calò, Clementina Bianchi, Michele Morari, Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release. Journal of Neurochemistry. ,vol. 91, pp. 1501- 1504 ,(2004) , 10.1111/J.1471-4159.2004.02843.X
U Simonsen, B E Laursen, J S Petersen, ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries. British Journal of Pharmacology. ,vol. 153, pp. 1185- 1194 ,(2008) , 10.1038/SJ.BJP.0707688
Catherine Mollereau, Marc Parmentier, Pierre Mailleux, Jean-Luc Butour, Christiane Moisand, Pascale Chalon, Daniel Caput, Gilbert Vassart, Jean-Claude Meunier, ORL1, a novel member of the opioid receptor family: Cloning, functional expression and localization FEBS Letters. ,vol. 341, pp. 33- 38 ,(1994) , 10.1016/0014-5793(94)80235-1
Toshiya Manabe, Yukihiro Noda, Takayoshi Mamiya, Hiroyuki Katagiri, Takeshi Houtani, Miyuki Nishi, Tetsuo Noda, Tomoyuki Takahashi, Tetsuo Sugimoto, Toshitaka Nabeshima, Hiroshi Takeshima, Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors Nature. ,vol. 394, pp. 577- 581 ,(1998) , 10.1038/29073
G. Carra', G. Calo', B. Spagnolo, R. Guerrini, M. Arduin, E. Marzola, C. Trapella, D. Regoli, S. Salvadori, Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2. Journal of Peptide Research. ,vol. 66, pp. 39- 47 ,(2008) , 10.1111/J.1399-3011.2005.00272.X
Paola F. Zaratin, Giuseppe Petrone, Massimo Sbacchi, Martine Garnier, Claudia Fossati, Paola Petrillo, Silvio Ronzoni, Giuseppe A. M. Giardina, Mark A. Scheideler, Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111). Journal of Pharmacology and Experimental Therapeutics. ,vol. 308, pp. 454- 461 ,(2004) , 10.1124/JPET.103.055848
Roberto Ciccocioppo, Daina Economidou, Roberto Rimondini, Wolfgang Sommer, Maurizio Massi, Markus Heilig, Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System Biological Psychiatry. ,vol. 61, pp. 4- 12 ,(2007) , 10.1016/J.BIOPSYCH.2006.01.006
Alexander Kuzmin, Mary Jeanne Kreek, Georgy Bakalkin, Sture Liljequist, The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking. Neuropsychopharmacology. ,vol. 32, pp. 902- 910 ,(2007) , 10.1038/SJ.NPP.1301169