High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications.

作者: Kylie L. Gorringe , Sharoni Jacobs , Ella R. Thompson , Anita Sridhar , Wen Qiu

DOI: 10.1158/1078-0432.CCR-07-0502

关键词: Ovarian cancerGeneticsBreakpointDNA microarrayTumor suppressor geneGenomeLoss of heterozygosityGene duplicationBiologySingle-nucleotide polymorphism

摘要: … protein kinase kinase 4 (MAP2K4) gene was detected in one … Somatic mutations in MAP2K4, located on 17p12, have been … No point mutations in MAP2K4 in ovarian cancer have been …

参考文章(41)
Xiaojun Zhao, Barbara A. Weir, Thomas LaFramboise, Ming Lin, Rameen Beroukhim, Levi Garraway, Javad Beheshti, Jeffrey C. Lee, Katsuhiko Naoki, William G. Richards, David Sugarbaker, Fei Chen, Mark A. Rubin, Pasi A. Jänne, Luc Girard, John Minna, David Christiani, Cheng Li, William R. Sellers, Matthew Meyerson, Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis Cancer Research. ,vol. 65, pp. 5561- 5570 ,(2005) , 10.1158/0008-5472.CAN-04-4603
Pasi A Jänne, Cheng Li, Xiaojun Zhao, Luc Girard, Tzu-Hsiu Chen, John Minna, David C Christiani, Bruce E Johnson, Matthew Meyerson, High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines Oncogene. ,vol. 23, pp. 2716- 2726 ,(2004) , 10.1038/SJ.ONC.1207329
Jonathan Sebat, B Lakshmi, Jennifer Troge, Joan Alexander, Janet Young, Par Lundin, Susanne Manér, Hillary Massa, Megan Walker, Maoyen Chi, Nicholas Navin, Robert Lucito, John Healy, James Hicks, Kenny Ye, Andrew Reiner, T Conrad Gilliam, Barbara Trask, Nick Patterson, Anders Zetterberg, Michael Wigler, Large-Scale Copy Number Polymorphism in the Human Genome Science. ,vol. 305, pp. 525- 528 ,(2004) , 10.1126/SCIENCE.1098918
Ashleen Shadeo, Wan L Lam, Comprehensive copy number profiles of breast cancer cell model genomes Breast Cancer Research. ,vol. 8, pp. 1- 14 ,(2006) , 10.1186/BCR1370
M. Baudis, M. L. Cleary, Progenetix.net: an online repository for molecular cytogenetic aberration data. Bioinformatics. ,vol. 17, pp. 1228- 1229 ,(2001) , 10.1093/BIOINFORMATICS/17.12.1228
Max Chaffanet, Véronique Gelsi-Boyer, Béatrice Orsetti, Nathalie Cervera, Pascal Finetti, Fabrice Sircoulomb, Carole Rougé, Laurence Lasorsa, Anne Letessier, Christophe Ginestier, Florence Monville, Séverine Esteyriès, José Adélaïde, Benjamin Esterni, Catherine Henry, Stephen P. Ethier, Frédéric Bibeau, Marie-Joëlle Mozziconacci, Emmanuelle Charafe-Jauffret, Jocelyne Jacquemier, François Bertucci, Daniel Birnbaum, Charles Theillet, Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Molecular Cancer Research. ,vol. 3, pp. 655- 667 ,(2005) , 10.1158/1541-7786.MCR-05-0128
Joseph R. Testa, Gonosuke Sonoda, Juan Palazzo, Stanislas du Manoir, Andrew K. Godwin, Madelyn Feder, Michiaki Yakushiji, Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas Genes, Chromosomes and Cancer. ,vol. 20, pp. 320- 328 ,(1997) , 10.1002/(SICI)1098-2264(199712)20:4<320::AID-GCC2>3.0.CO;2-3
Colleen M. Feltmate, Kenneth R. Lee, Michael Johnson, John O. Schorge, Kwong-kwok Wong, Ke Hao, William R. Welch, Debra A. Bell, Ross S. Berkowitz, Samuel C. Mok, Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas Clinical Cancer Research. ,vol. 11, pp. 7651- 7657 ,(2005) , 10.1158/1078-0432.CCR-05-1008
Carrie W. Rinker-Schaeffer, Theodore Karrison, Anthony Montag, Jonathan A. Hickson, Sarah Adams, Donald J. Vander Griend, David Benson, Dezheng Huo, S. Diane Yamada, Yancey Hrobowski, Joanne Rutgers, Mitogen-activated Protein Kinase Kinase 4 (MKK4) Acts as a Metastasis Suppressor Gene in Human Ovarian Carcinoma Cancer Research. ,vol. 62, pp. 6717- 6723 ,(2002)