Future possibilities in the prevention of breast cancer: Breast cancer prevention trials

摘要: The available results from breast cancer chemoprevention trials are reviewed. Four using tamoxifen have been performed, of which three reported efficacy results. A fifth trial raloxifene has also reported. largest showed approximately 50% reduction in incidence the short term, but two smaller did not find any reduction. Greater agreement exists for side effects; incidences thromboembolic disease and endometrial cancers raised threefold when is used 5 years. possible reasons discrepancy explored. review parameters does clearly explain this difference, a meta-analysis indicates that all compatible with 40% short-term incidence. Several important questions remain regarding clinical implications result, including effect on mortality, appropriate risk groups long-term effects Continued follow up these crucial resolving issues.