Role of hypogonadism in development of bone alterations in thalassemic patients

摘要: Although transfusions and chelation therapy have improved survival of patients afflicted with Thalassemia Major (TM), endocrine alterations are still common complications. Particularly, hypogonadism plays an important role in the aetiology of osteoporosis these patients. It is clear that most patients the gonadal failure a consequence pituitary damage and hypogonadotropic hypogonadism occurs; nevertheless, also damage because iron deposition may be further cause hypogonadism. Prevalence the pubertal ranges between 50 to 80% cases. In some studies ferritin levels been correlated hypogonadism, suggesting improvement treatments may prevent or reduce appearance in TM Treatment HRT has shown conflicting results, but who started treatment young age present better results than those later. However we may conclude option but should prescribed early associated biphosphonates