Laser-activated PLGA theranostic agents for cancer therapy in vivo
作者： Yang Sun , Chengcheng Niu , Yuanyi Zheng , Haitao Ran , Rongzhong Huang
关键词: Electron microscope 、 Perfluorohexane 、 PLGA 、 Biophysics 、 Colloidal gold 、 Squamous carcinoma 、 In vivo 、 Lymph 、 Irradiation 、 Chemistry 、 Nanotechnology
摘要: Poly (lactide-co-glycolic acid) (PLGA) particles are biocompatible FDA approved materials that can be used for diagnostic and therapy applications. Micron-sized PLGA were synthesized with gold nanoparticles DiI dye within the shell, perfluorohexane liquid (PFH) in core. The core is activated upon laser irradiation, resulting a rapidly expanding microbubble; damage to surrounding cells tissue occur. effect of anticancer was examined rabbits metastasized squamous carcinoma lymph nodes. After decreased blood perfusion necrotic regions observed treated compared control. Electron microscopy histology confirmed nodes; disrupted throughout, slowing tumor growth rate. This study demonstrates capability containing PFC liquids as theranostic agents in-vivo.
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