Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method.
作者： Xiaoli Duan , Guofeng Shen , Hongbiao Yang , George Lambert , Fusheng Wei
DOI: 10.1016/J.ENVPOL.2015.10.023
关键词: CYP1A2 、 Internal medicine 、 Benzo(a)pyrene 、 Environmental chemistry 、 Pyrene 、 Exhalation 、 Endocrinology 、 Ingestion 、 Carcinogen 、 Chemistry 、 Inhalation 、 Inhalation exposure
摘要: Cytochrome P450 1A2 (CYP1A2) is an enzyme involved in the metabolic activation of certain carcinogens, and inducible by toxic substrates. To date, few studies have investigated vivo CYP1A2 induction humans its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP). Non-smoking healthy male coke-oven workers (n = 30) were recruited as 'exposure' group, non-smoking office same city 10) selected 'control' test whether high inhalation exposure PAHs can induce activity human livers. Significantly higher found among group compared control. Inhalation BaP concentration was more than 30 times control (p < 0.001). However, did not exhale significant levels (13)CO2/(12)CO2 breath samples 0.81), no between inhaled ratio 0.91). A association exhalation dietary intake level. Hepatic activity/induction level effected but altered ingestion BaP.
sci-hub.se 参考文章(31)
Kadlubar Ff, Sinha R, Landi Mt, Lang Np, Human cytochrome P4501A2. IARC scientific publications. pp. 173- 195 ,(1999)
Tsutomu Shimada, Hiroshi Yamazaki, Maryam Foroozesh, Nancy E. Hopkins, William L. Alworth, F. Peter Guengerich, Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chemical Research in Toxicology. ,vol. 11, pp. 1048- 1056 ,(1998) , 10.1021/TX980090+
Yanxu Zhang, Shu Tao, Huizhong Shen, Jianmin Ma, Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 21063- 21067 ,(2009) , 10.1073/PNAS.0905756106
Gordon Jung-Hyuk Park, Peter Harry Katelaris, Brian D Jones, Francis Seow, David George Le Couteur, Meng Chong Ngu, Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function* Hepatology. ,vol. 38, pp. 1227- 1236 ,(2003) , 10.1053/JHEP.2003.50475
Ian C.T. Nisbet, Peter K. LaGoy, Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regulatory Toxicology and Pharmacology. ,vol. 16, pp. 290- 300 ,(1992) , 10.1016/0273-2300(92)90009-X
Fabiola Castorena-Torres, Ania Mendoza-Cantú, Mario Bermúdez De León, Bulmaro Cisneros, Omar Zapata-Pérez, Lizbeth López-Carrillo, Juan E Salinas, Arnulfo Albores, None, CYP1A2 phenotype and genotype in a population from the Carboniferous Region of Coahuila, Mexico. Toxicology Letters. ,vol. 156, pp. 331- 339 ,(2005) , 10.1016/J.TOXLET.2004.12.005
Robert J. Fontana, Kenneth S. Lown, Mary F. Paine, Laurie Fortlage, Regina M. Santella, James S. Felton, Mark G. Knize, Arthur Greenberg, Paul B. Watkins, Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology. ,vol. 117, pp. 89- 98 ,(1999) , 10.1016/S0016-5085(99)70554-8
Hemda Schmilovitz-Weiss, Yaron Niv, Orit Pappo, Marisa Halpern, Jacklin Sulkes, Marius Braun, Nir Barak, Yaron Rotman, Maya Cohen, Amal Waked, Ran Tur-Kaspa, Ziv Ben-Ari, The 13C-caffeine breath test detects significant fibrosis in patients with nonalcoholic steatohepatitis. Journal of Clinical Gastroenterology. ,vol. 42, pp. 408- 412 ,(2008) , 10.1097/MCG.0B013E318046EA65
Edward F. Fitzgerald, Syni-An Hwang, George Lambert, Marta Gomez, Alice Tarbell, PCB exposure and in vivo CYP1A2 activity among Native Americans. Environmental Health Perspectives. ,vol. 113, pp. 272- 277 ,(2004) , 10.1289/EHP.7370
Dilip D. Vakharia, Ning Liu, Ronald Pause, Michael Fasco, Erin Bessette, Qing-Yu Zhang, Laurence S. Kaminsky, Effect of Metals on Polycyclic Aromatic Hydrocarbon Induction of CYP1A1 and CYP1A2 in Human Hepatocyte Cultures Toxicology and Applied Pharmacology. ,vol. 170, pp. 93- 103 ,(2001) , 10.1006/TAAP.2000.9087