Frontal lobe of children with schizophrenia spectrum disorders: A proton magnetic resonance spectroscopic study
作者： William M. Brooks , Janet Hodde-Vargas , Luis A. Vargas , Ronald A. Yeo , Corey C. Ford
DOI: 10.1016/S0006-3223(97)00462-9
关键词: Risk factor 、 Frontal lobe 、 Internal medicine 、 Schizophrenia 、 Psychology 、 Magnetic resonance imaging 、 Psychosis 、 Gastroenterology 、 Neurochemistry 、 Creatine 、 Neurodevelopmental disorder 、 Psychiatry
摘要: Background: Schizophrenia is commonly considered a neurodevelopmental disorder. Our aim was to determine whether the proton magnetic resonance spectroscopic (1H-MRS) changes seen in adults with schizophrenia are displayed children at risk for developing schizophrenia. Methods: Children symptoms of schizophrenia-spectrum disorders (n = 16; mean age 132 months) and comparison group 12; 130 took part 1H-MRS study left frontal lobe. Areas peaks from N-acetylaspartate (NAA), choline (Cho), creatine (Cre) were determined ratios NAA/Cre Cho/Cre calculated compared between groups. Results: The ratio significantly lower subjects than (1.67 vs. 1.92; p < .05). Medication status did not affect results subjects. Conclusions: Our findings suggest that metabolic associated adult observed some or all schizophrenia, supporting theory schizophrenia.
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