Clavirolide G, a new rare dolabellane-type diterpenoid from the Xisha soft coral Clavularia viridis
作者： Yuan Gao , Wei Xiao , Hong-Chun Liu , Jian-Rong Wang , Li-Gong Yao
DOI: 10.1016/J.CCLET.2017.01.004
关键词: Human tumor 、 Terpenoid 、 South china 、 Chemistry 、 Absolute configuration 、 Circular dichroism 、 Coral 、 Stereochemistry 、 Clavularia viridis
摘要: Abstract One new dolabellane-type diterpenoid, named clavirolide G (1), and one known related analogue (3), have been isolated from the soft coral Clavularia viridis collected off Xisha Islands in South China Sea. Its structure absolute configuration were determined on basis of spectroscopic analysis, electronic circular dichroism, compared with literature model compounds. The cytotoxic activity these two compounds was evaluated against a panel human tumor cell lines. Compound 1 showed moderate KB HL-60 cells.
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