Krüppel-like Factors in Stem Cell Biology
作者： Masatsugu Ema , Satoru Takahashi , Yoshiaki Fujii-Kuriyama
DOI: 10.1007/978-4-431-87775-2_10
关键词: Cell biology 、 Embryonic stem cell 、 Induced pluripotent stem cell 、 Germ layer 、 Reprogramming 、 Cell 、 Blastocyst 、 Biology 、 Somatic cell 、 Regenerative medicine
摘要: Embryonic stem (ES) cells are derived from the blastocyst and have potential to give rise derivatives of each germ layer. Induced pluripotent (iPS) can be lineage-restricted cells, such as fibroblasts lymphocytes, by forced expression specific transcription factors. iPS transcriptionally epigenetically similar ES cells. Although recent studies indicate that Kruppel-like factors (KLFs) essential for both maintenance cell self-renewal reprogramming somatic into a state, molecular mechanism these processes remains unknown. Thus, understanding Klfs is important efficient generation patient-specific development regenerative medicine.
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