The influence of rejection on graft motility after intestinal transplantation in swine: the possibility of using this method for the real-time monitoring of acute cellular rejection
作者： Toshiharu Matsuura , Tomoaki Taguchi , Makoto Hayashida , Keiko Ogita , Narito Takada
DOI: 10.1016/J.JPEDSURG.2007.03.038
关键词: Contractility 、 Stage (cooking) 、 Histology 、 Medicine 、 Transplantation 、 Acute cellular rejection 、 Stoma 、 Migrating motor complex 、 Motility 、 Gastroenterology 、 Internal medicine 、 Pathology 、 Pediatrics, Perinatology, and Child Health 、 Surgery 、 General Medicine
摘要: Abstract Background We have previously reported that rejected allografts show dysmotility, which can be detected by real-time monitoring in swine. examined the correlation between motility and mucosal histology to detect rejection at an early stage monitoring. Methods Intestinal transplantation was performed orthotopically using FK506. The distal segment of allograft measuring about 20 cm isolated exteriorized as "Thiry-Vella" stoma for biopsies. Strain-gage force transducers were attached on a graft motility. pigs without intestinal used controls (C). classified into 4 groups based histologic findings: nonrejection, mild rejection, moderate severe rejection. Migrating motor complex (MMC) phase 3 estimated following parameters: duration, amplitude, interval, index, velocity, frequency propagation. Results In nonrejection group, all parameters almost same C group. contrast, groups, most significantly lower than those contractility MMC not altered, but propagation decreased significantly. Conclusions strain-gage method correlated closely grade histology. This is therefore considered useful detecting examining
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