Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination.
作者： Céline Verheust , Martine Goossens , Katia Pauwels , Didier Breyer
DOI: 10.1016/J.VACCINE.2012.02.016
关键词: Genetically modified organism 、 Context (language use) 、 Virology 、 Gene delivery 、 Vaccinia 、 Vaccination 、 Virus 、 Genetic enhancement 、 Immunology 、 Biosafety 、 Biology
摘要: The modified vaccinia virus Ankara (MVA) strain is a highly attenuated of that has been demonstrated to be safe for humans. MVA widely considered as the choice clinical investigation because its high safety profile. It also represents an excellent candidate use vector system in recombinant vaccine development gene delivery or vaccination against infectious diseases tumours, even immunocompromised individuals. and vectors must comply with various regulatory requirements, particularly relating assessment potential risks human health environment. purpose present paper highlight some biological characteristics MVA-based discuss these from biosafety point view context European framework genetically organisms emphasis on associated environmental release.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(90)
Friedrich v. Rheinbaben, Jürgen Gebel, Martin Exner, Axel Schmidt, Environmental resistance, disinfection, and sterilization of poxviruses Poxviruses. pp. 397- 405 ,(2007) , 10.1007/978-3-7643-7557-7_19
Müller Hk, Danner K, Stickl H, Singer H, Mayr A, [The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, Praventive Medizin. ,vol. 167, pp. 375- 390 ,(1978)
Bernd Spriewald, Dieter Willbold, Marion Rittmaier, Joachim R. Kalden, Maria Tzatzaris, Michael Bäuerle, Kathrin Eismann, Barbara Petzold, Paul Chaplin, Jens Vollmar, Silke Bergmann, Ellen Harrer, Thomas Harrer, Sandra Müller, Amanda Handley, Barbara Ferstl, Luis Mateo, Therapeutic vaccination of HIV-1-infected patients on HAART with a recombinant HIV-1 nef-expressing MVA: safety, immunogenicity and influence on viral load during treatment interruption. Antiviral Therapy. ,vol. 10, pp. 285- 300 ,(2005)
C. Staib, I. Drexler, M. Ohlmann, S. Wintersperger, V. Erfle, G. Sutter, Transient host range selection for genetic engineering of modified vaccinia virus Ankara. BioTechniques. ,vol. 28, pp. 1137- 1148 ,(2000) , 10.2144/00286ST04
L A Ball, High-frequency homologous recombination in vaccinia virus DNA. Journal of Virology. ,vol. 61, pp. 1788- 1795 ,(1987) , 10.1128/JVI.61.6.1788-1795.1987
Birgit Schramm, Jacomine Krijnse Locker, Cytoplasmic organization of POXvirus DNA replication. Traffic. ,vol. 6, pp. 839- 846 ,(2005) , 10.1111/J.1600-0854.2005.00324.X
Rodryg Ramlau, Elisabeth Quoix, Janusz Rolski, Miklos Pless, Herve Lena, Eric Lévy, Maciej Krzakowski, Dagmar Hess, Eric Tartour, Marie-Pierre Chenard, Jean-Marc Limacher, Nadine Bizouarne, Bruce Acres, Céline Halluard, Thierry Velu, A Phase II Study of Tg4010 (Mva-Muc1-Il2) in Association with Chemotherapy in Patients with Stage III/IV Non-small Cell Lung Cancer Journal of Thoracic Oncology. ,vol. 3, pp. 735- 744 ,(2008) , 10.1097/JTO.0B013E31817C6B4F
Jeffrey R. Currier, Viseth Ngauy, Mark S. de Souza, Silvia Ratto-Kim, Josephine H. Cox, Victoria R. Polonis, Patricia Earl, Bernard Moss, Sheila Peel, Bonnie Slike, Somchai Sriplienchan, Prasert Thongcharoen, Robert M. Paris, Merlin L. Robb, Jerome Kim, Nelson L. Michael, Mary A. Marovich, Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate PLoS ONE. ,vol. 5, pp. e13983- ,(2010) , 10.1371/JOURNAL.PONE.0013983
R. Dreicer, W. M. Stadler, F. R. Ahmann, T. Whiteside, N. Bizouarne, B. Acres, J.-M. Limacher, P. Squiban, A. Pantuck, MVA-MUC1-IL2 vaccine immunotherapy (TG4010) improves PSA doubling time in patients with prostate cancer with biochemical failure. Investigational New Drugs. ,vol. 27, pp. 379- 386 ,(2009) , 10.1007/S10637-008-9187-3
Juan C. Ramírez, M. Magdalena Gherardi, Mariano Esteban, Biology of Attenuated Modified Vaccinia Virus Ankara Recombinant Vector in Mice: Virus Fate and Activation of B- and T-Cell Immune Responses in Comparison with the Western Reserve Strain and Advantages as a Vaccine Journal of Virology. ,vol. 74, pp. 923- 933 ,(2000) , 10.1128/JVI.74.2.923-933.2000